St. Mark's Coptic Orthodox Cathedral is located in the Abbassia District in Cairo, Egypt. It is the current seat of the Coptic Orthodox Pope. It was built during the time when Pope Cyril VI of Alexandria was Pope of the Coptic Orthodox Church and inaugurated by Pope Cyril in 1968.
History of the land
Historically the land where the Cathedral stands has been used for centuries as a cemetery for the Copts; this land had the historic Anba Rouis' Church.
The land had been given to the Coptic Orthodox Church in 969 by Gawhar. This land was given as a replacement for the land that was taken from the church to be included in building the Palace of Ma'ad al-Muizz Li-Deenillah as part of the planning of the new capital of Egypt, Cairo. 
During the twelfth century the area contained ten Coptic churches, but during the rule of Qalawun on 18 February 1280 the churches were destroyed by the persecutors of the Copts. Two churches were subsequently built in the area under the rule of his son. 
In 1943 the governerate of Cairo attempted to expropriate the area for public use. This was opposed by the General Congregation Council led by its secretary at the time Mr. Habib Elmasry; their campaign proved successful as the Coptic Church maintained control of the land under the condition that a non-profit building be built on it in the following fifteen years. This condition spurred the building of the cathedral. 
The cathedral is considered a unique example of architectural evolution which includes seven churches of which some have a great historic value such as Anba Rouis' Church. The Cathedral represents the rapid development of Coptic architecture, the famous Coptic civil engineer Michel Bakhoum contributed in its structural design.
Relics of Saint Mark
Before the completion of the Cathedral, the Roman Catholic pontiff of the time, Pope Paul VI, returned part of St. Mark's relics, which were stolen from Egypt in the year 828, and taken to Venice, Italy. These relics were taken to the newly constructed Cathedral, where they were placed in a specially built shrine brightly decorated with Coptic icons. They still remain there today. The Coptic Cathedral of St. Mark is by far the largest Cathedral in Africa and the Middle East. This claim can still be valid as contrary to popular belief of the largest "cathedral" being the Basilica of Our Lady of Peace of Yamoussoukro in Yamoussoukro, the administrative capital of Côte d'Ivoire (Ivory Coast), which is considered the largest church in the world but not a cathedral. The nearby Cathedral of Saint Augustine is the principal place of worship and seat of the bishop of the Diocese of Yamoussoukro.
The inauguration of the new Saint Mark's Coptic Orthodox Cathedral took place on June 25, 1968  in a ceremony attended by Egyptian President Gamal Abdel Nasser, Ethiopian Emperor Haile Selassie, among other foreign clergy members from other churches. It is the seat of the current Coptic Pope, His Holiness Pope Shenouda III, Pope and Patriarch of Alexandria and the See of St. Mark.
- دير الأنبا رويس
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- "Churches in Egypt". Egyptvoyager.com. http://www.egyptvoyager.com/features_christianmonuments_churches.htm. Retrieved 2009-05-06.
- "Pope Saint Kyrillos VI (Cyril VI), 116th Pope of Alexandria". Zeitun-eg.org. http://www.zeitun-eg.org/stcyril6.htm. Retrieved 2009-05-06.