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He became a monk in his early years in the desert of Scete. He continued to fight and to devote himself to God for sixteen years. He was ordained a deacon in the monastery of St. John the Short. Then he went to the monastery of the fathers which is to the west of Alexandria, and there he increased his asceticism.
When Pope Peter (34) was enthroned on the See of St. Mark, he brought and appointed Damianos a private secretary. Damianos pursued a good course of life and everyone loved him. When Pope Peter departed, the bishop unanimously agreed to ordain him a patriarch. He was enthroned a patriarch on the second of Abib 285 A.M. (June 26, 569 A.D.). He cared for his flock well and he wrote many epistles and discourses.
In the wilderness of Scete, there were some followers of Melitius El-Assyuty, who drank wine a few times during the night before they intended to partake of the Holy Communion. They claimed that the Lord Christ gave to His disciples two cups: the first He did not say, "This is My Blood" but when he gave them the second cup he said, "This is My Blood." St. Damianos showed them their error. He clarified to them that the first cup was the cup of the Jewish passover, and He nullified it with the second cup. He also told them that the canons of the church ban those that eat before communion from partaking of the Holy Eucharist. Some of them turned from their evil, but those that did not turn from their evil council were driven out of the wilderness. When Anba Theophanius, the Antiochian Patriarch departed, they ordained a successor to him called Peter, who sent a letter to Pope Damianos which said, "There is no need for us to say that God is the three Persons." When Pope Damianos read this letter he became enkindled with zeal. He wrote him a letter which explained that God is, in no doubt, one in His Godhead, one in essence, but He is Three persons, God the Father, God the Son, God the Holy Spirit, One God. He wrote to him many testimonies from the Holy Scriptures and from the sayings of the holy fathers. Nevertheless, Peter refused to return to the truth, and insisted on his error. Pope Damianos ordered that his name not be mentioned in the Divine Liturgy for twenty years until the heretic died.
Pope Damianos remained for thirty five years, eleven month, and sixteen days, teaching and preaching to his flock. He departed at a good old age.